Stephen Gwaltney

Stephen Gwaltney

Company: SpringWorks Therapeutics

Job title: Head of Drug Discovery

Seminars:

Discovery & Development of Novel YAP/TAZ-TEAD Antagonists 10:00 am

Activity of the YAP/TAZ-TEAD complex represents a compelling pharmacologic target We have identified novel small molecules that bind to the TEAD autopalmitoylation pocket; these compounds are highly potent, orally bioavailable and active against multiple cancer cell lines In vivo models of Hippo pathway-altered xenografts showed that our inhibitors deliver consistent monotherapy activity, with dose-dependent and…Read more

day: Day Two

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