Shaun Stauffer

Shaun Stauffer

Company: Cleveland Clinic

Job title: Director


Leveraging NMR Fragment Screening Method to Identify Starting Points for Optimization & Disruption of the YAP/TAZ-TEAD Interaction to Develop Structurally Unique Lead-like Chemotypes for TEAD Inhibition 11:45 am

Pinpointing the approach to develop a streamlined NMR screening platform to identify putative TEAD binders and hit assessment Showcasing a pipeline in structural science to allow X-ray structure determination of putative hit fragments Highlighting how mode of inhibition and kinetics of TEAD binders are defined based on crystallography and biophysical evaluationRead more

day: Conference Day One

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