MSC-4106: From TEAD P-Site Binding Fragment into In Vivo Active Lead

Time: 2:00 pm
day: Day Two


  • Fragment hit identification and structure enabled optimization
  • TEAD 1/2/3/4 selectivity investigations based on thermal shift and palmitoylation assays for MSC-4106 and a couple of published covalent and reversible P-site and surface binder
  • In vivo efficacy and PD biomarker correlation for MSC-4106