Leveraging NMR Fragment Screening Method to Identify Starting Points for Optimization & Disruption of the YAP/TAZ-TEAD Interaction to Develop Structurally Unique Lead-like Chemotypes for TEAD Inhibition

Time: 11:45 am
day: Conference Day One


  • Pinpointing the approach to develop a streamlined NMR screening platform to identify putative TEAD binders and hit assessment
  • Showcasing a pipeline in structural science to allow X-ray structure determination of putative hit fragments
  • Highlighting how mode of inhibition and kinetics of TEAD binders are defined based on crystallography and biophysical evaluation