Discovery & Development of Novel YAP/TAZ-TEAD Antagonists

Time: 10:00 am
day: Day Two


  • Activity of the YAP/TAZ-TEAD complex represents a compelling pharmacologic target
  • We have identified novel small molecules that bind to the TEAD autopalmitoylation pocket; these compounds are highly potent, orally bioavailable and active against multiple cancer cell lines
  • In vivo models of Hippo pathway-altered xenografts showed that our inhibitors deliver consistent monotherapy activity, with dose-dependent and durable tumor regressions achieved at well-tolerated doses