Development of Covalent TEAD Inhibitor to Suppress Defective Hippo Signaling

Time: 3:30 pm
day: Conference Day Two


  • Covalent Targeting TEAD Palmitoylation cysteine 
  • Covalent inhibition of TEAD suppresses TEAD-regulated gene expression
  • Covalent TEAD inhibitor inhibits the proliferation of the cell with TEAD/YAP dependence 
  • Orally bioavailable TEAD Covalent Inhibitor demonstrates anti-tumor effect on mesothelioma mouse model.