Development of Covalent TEAD Inhibitor to Suppress Defective Hippo Signaling
Time: 3:30 pm
day: Conference Day Two
Details:
- Covalent Targeting TEAD Palmitoylation cysteine
- Covalent inhibition of TEAD suppresses TEAD-regulated gene expression
- Covalent TEAD inhibitor inhibits the proliferation of the cell with TEAD/YAP dependence
- Orally bioavailable TEAD Covalent Inhibitor demonstrates anti-tumor effect on mesothelioma mouse model.
