Building Towards Subtype Specific Degraders of TEADs Based on Interface 3 Binding

Time: 2:00 pm
day: Conference Day Two


  • Elucidating how pan-TEAD binders targeting interface 3 can be used as disruptors of the YAP/TEAD protein-protein interaction
  • Showcasing subtype specific degraders of TEADs, based on interface 3 binders, being optimized by using a ternary complex formation assay
  • Demonstrating how a TEAD degrader, in contrast to palmitoylation inhibitors, will block all transcriptional activation by TEAD and hence is expected to be more efficacious as a cancer treatment.